I've posted this advice several times on KLR forums:I have an E52 top case with V35 side cases and only notice the side cases trying to get my old leg over them to get on or off. I am sure they affect handling some, but not enough to worry about.
Was in Coos Bay, Oregon all weekend. Beautiful ride over, beautiful ride back to Eugene.Hey Nvoelsch, where you gonna be this weekend? With two 18-packs AND a backpack full of more beer, I want to be at that party.
I have Givi E21s and never notice a change in performance or handling. And, I agree that backpacks can throw off balance in high wind.