Opinion on vibration seems to be mixed, and may vary between machines. Many claim it's hardly noticeable, others (myself included) will put it slightly on the buzzy side of things. I get tingly hands or occasionally feet after a couple of hours, otherwise it's not bad. Height and reach are great for those of us taller folk, but the seat-to-footpeg span folds my 34" inseam just wee bit more than I'd like. Speedy's
peg lowering kit is said to be a fantastic and easy fix. Another notable beef is with the turbulence the screen introduces around my helmet. Experimentation seems to be the only remedy here, and there is extensive documentation available here with a search. Experience on this point differs GREATLY between riders. Stock tires have fantastic wear but relatively poor wet performance. Brake feel is a little fuzzy, but there's more than enough stopping power. And as a final thumbs-down, resale value is poor.
On the positive side, reliability is nearly uniformly excellent, and the seat is reasonable after a bit (quite a bit, really) of break-in. Handling is exceptional for the price class, though I and others find the stock rear shock slightly sub-optimal. Fuel economy is great as well; I manage 50mpg +/-2 in warm weather. Aftermarket support is surprisingly strong, and many Ninja/ER-6 bits will bolt right on. Also, there's a fantastic forum for when you can't figure something out on your own.
Lots of cross-shop goes on between the Versys and 'Strom. More off-road oriented types favor the Suzuki, with road warriors like me biased toward the Versys. A more DS-like V can be done and done well (just ask jdrocks), but it doesn't fit the bill right out of the box. I will now cut myself off before this post devolves into terminal ramble.