Anatomically, Grip Puppies work wonderful if you have 6' tall man hands or taller. It keeps you from cramping your grip down (very painful on distant driving.) If you are 'significantly' shorter, the Vs. 650 might pull the bars out of your hands (whoops!) when you hammer the throttle down since you can not grip the bigger grip enough to hold on (acceleration > grip force.)
It's only $25 shipped, so you will never know until you try it. But if your hands get cramped often, from repetitive trauma disorder via hand cramps and stagnated blood, you will love it if it is installed correctly. It's not hard. And numb hands will only be when you grip it hard (like you tend to do if the grip is too small) vs almost every time you grip a smaller diameter grips with big hands.
Take care of your hands while you can.