Yes it is possible, it happened to one of my bikes. Something inside the exhaust got lose and it rattled at an specific RPM, or a direct hit to the muffler. The way these things are made, you can only replace it, there is no way of knowing what and where it is lose.
When I opened the OEM silencer up I found (in my case) that the perforated cap at the end of the tube with the Cat in it (just behind the front silencer wall) was loose.
This is some else doing the same thing but I have not got a picture of it in place
Top cap removed in this picture of mine
It is held on by three little tack welds and one had broken so it was loose / vibrating.
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