I think it is going to come down to a "what works for you" type of thing.
A couple ideas come to mind.
You could look at an inexpensive throttle lock. This isn't a cruse control, but rather it just holds the throttle to a set position, giving you the chance to stretch your wrist, shake it out, etc. I think you can find an inexpensive one for $20 or so. I've heard of using an o-ring where the throttle meets the bar end weight, but I've never tried it.
Also, try adjusting your hand position and or look bar risers.
For the brake, what type of boots are you wearing? There is quite a bit of adjustment in the brake position, maybe you just need to move it. On a longer ride, change foot position once in a while, even if just to stretch out. Move your foot on the peg from the arch area to the ball. On longer rides, I will even move my feet up to the rear pegs just for a different position for a while. Some may say that is a less "ready to brake" position, but it can't be any worse than having them on highway pegs.
You always want to be prepared to respond to a situation, but maybe you are riding a little too tense?
With a few modifications, the Versys can be a decent touring bike. I've done 600 mile days and several 400 mile consecutive day trips.