Jab, I've used that stuff in the last 7 tires at least, and I've never noticed any vibration, even at the start.
I just put in the amount they say, blow off any residue on the valve stem's female threading, screw the valve back in but not tight, just slightly snug, fill the tire with air to the correct pressure, and then just roll the tire around several times. Once I go off and ride, it just feels smooth all the time.
A few times my bike has set for just several days without riding and when I ride it again, it just feels smooth.
Maybe if we had one of those BIG ass rear tires that look like a truck tire which would require a lot of Ride-On, then maybe that could cause a bit of vibration at first if you home was right on the hwy and immediately did 70 mph, but that's not us.