I have not ridden a CBR but I have ridden a Yamaha R1. The big difference is in the peg placement. The R1's pegs are back and up, I'm assuming similar to the CBR, giving you a more tucked position where as the V's pegs are almost straight below your hips thus giving you a "ready" stance. I don't know if you played any sports but in football or basketball you have the "ready" stance feet spread shoulders apart in a squat "ready" to react. I have a 36" inseam and find the V more comfortable compared to anything else I have ridden, besides a lazy feet forward cruiser.
one of my friends had a 2002 F4i and it was a comfortable bike (back when sportbikes were comfortable too). I will say the Versys seems much more roomy than the F4i and a bit more upright. Your legs will be in a little bit of a sportbike position but not as extreme. All in all, the V is much more comfortable and roomier than the F4i but you will not get that I4 kick. The motor is torquey but not I4 powerful.
Good luck on your choice. I had a few sportbikes but grew tired of the position. The Versys is by far the best bike I've owned and would be right back at the dealer for another one if mine were somehow totaled or stolen (knock on wood that doesn't happen).
EDIT: for info, I'm 5'7" with a little less than a 30 inseam.
I would think you could find a long lasting compound for the rear tire no problem. My father can still find lots of different types for his 1978 Suzuki GS1000 and touring tires for his 86 BMW K-LT, so I'd figure if there's a tire out there for those, there has to be one for the Versys, I just haven't looked around for one yet.
There's plenty of people on the board here who have racked up the miles and I'm sure they'd have some suggestions.
Thats great, while I have everyones here I have a question.
The tires for the CBR lasted about 4000 miles, I went thru alot.
The tire size for the Versys, is it available in a compound that last maybe 10,000 miles. Talking rear tire
I own both bikes. Obviously the Versys is more confortable with a very upright seating. I would guess it has at least two more inches of leg room as well.
As far as tires I put Diablo Stradas on my F4i and my SV650S and get about 10k out of them. I will be putting them on my Versys as well when the time comes. Its a great tire for distance riding and the twisties.